Which statement about transdermal estradiol is true?

Transdermal estradiol is designed for slow and steady absorption through the skin into the systemic circulation. This method of delivery allows for a gradual increase in estradiol levels, which helps maintain consistent hormone levels in the body. The slow absorption is beneficial in minimizing the peaks and troughs that can occur with other forms of hormone delivery, such as oral administration, leading to more stable therapeutic effects.

While estradiol itself can have a relatively short half-life, which supports its use in transdermal formulations, the key characteristic of the transdermal route is the controlled absorption rate. Transdermal patches are typically designed for once-daily or less frequent application, as they provide a long-lasting release of the hormone, rather than requiring two applications per day. Therefore, the correct statement focusing on the slow absorption aligns accurately with how transdermal estradiol functions and is used in therapeutic settings.